With air travel there is no distance, there is only time.
Air travel, especially long haul flights, can be very exhausting. Getting to the airport 3 hours before the flight, endless queuing, cramped seating back in coach / economy, noise, dry air, and airports are just horrible places to spend much time… But it’s only recently that I’ve become prey to terrible jet-lag, which mostly affects me when I’m flying from west to east
There are some things that will reduce the effects of jet-lag, paying for a better seat, not drinking on the aircraft, and sleeping as much as possible on the journey. Melatonin helps too.
However, following my last trip to the USA, I have been wrecked for a week with jet-lag. But it’s all worth it when one has a great time on vacation. (And, I don’t do business travel any more.)
The best thing of all is seeing wonderful sights and creating great memories.